Nature Methods - Issue - nature.com science feeds
Nature Methods, Published online: 14 May 2024; doi:10.1038/s41592-024-02279-6The Consortium for Top-Down Proteomics conducted a study to develop and test protocols for native mass spectrometry combined with top-down fragmentation of proteins and protein complexes across eleven instruments in nine laboratories. They report the summary of the outcomes...
Nature Methods, Published online: 14 May 2024; doi:10.1038/s41592-024-02272-zOpenFold is a trainable open-source implementation of AlphaFold2. It is fast and memory efficient, and the code and training data are available under a permissive license.
Nature Methods, Published online: 10 May 2024; doi:10.1038/s41592-024-02269-8By effective and efficient integration of PacBio HiFi, Oxford Nanopore Technologies ultra-long and other sequencing data types, hifiasm (UL) enables telomere-to-telomere diploid and polyploid genome assembly at a population scale.
Nature Methods, Published online: 09 May 2024; doi:10.1038/s41592-024-02261-2We developed a two-pronged strategy to functionally probe the enormous repertoire of noncoding DNA within genomes. Our approach markedly improved signal-to-noise ratio and successfully intersected single-cell genomics with reporter assays. The result delivers a multiplex and...
Nature Methods, Published online: 09 May 2024; doi:10.1038/s41592-024-02274-xBy learning to embed DNA k-mers and cells into a joint space, CellSpace improves single-cell ATAC-seq analysis in multiple tasks such as latent structure discovery, transcription factor activity inference and batch effect mitigation.
Nature Methods, Published online: 09 May 2024; doi:10.1038/s41592-024-02260-3Single-cell quantitative expression reporters enable high-sensitivity quantitative characterization of cis-regulatory elements at the single-cell level in multicellular systems.
خوراک خبری خود را بسازید
آیا آماده هستید تا آن را اجرا کنید؟
بدون نیاز به کارت اعتباری، یک دوره آزمایشی 14 روزه را شروع کنید.