The Lancet
Almost 40 000 people died alone at home in Japan this year—many unnoticed for months—prompting much concern, and new policy. Megan Tatum reports.
These data demonstrate that beti-cel can allow patients with genotypes that cause severe β-thalassaemia (β0/β0, β0/β+IVS-I-110, or β+IVS-I-110/β+IVS-I-110) to reach transfusion independence. Beti-cel offers the potential to attain near-normal haemoglobin levels for those with severe forms of TDT, and a potentially curative option without the risks and...
Medical care for individual conditions is insufficient for improving overall health and reducing persistent disparities in morbidity and mortality in the USA. Social determinants of health (SDoH), which comprise economic stability, attained education, health-care access, neighbourhood characteristics, and community context, are root causes of health...
Since the current outbreak of mpox clade I began in eastern DR Congo in 2023, there has been a rapid increase in cases, primarily in DR Congo, and spread of the monkeypox virus to other countries in Africa.1–3 While 85% of mpox deaths in DR Congo since 2022 have occurred in children younger than 15 years,2 a new clade Ib strain, which is apparently...
Substantial disparities in wellbeing exist within the USA and are heavily influenced by race and ethnicity (due to racism), sex, age, and geographical location. These disparities are not immutable, but improvement is not a given, and gains can be fleeting in the face of a crisis such as the COVID-19 pandemic. Sustained action to ensure that everyone...
iCEPS transplantation for LSCD was found to be safe throughout the study period. A larger clinical trial is planned to further investigate the efficacy of the procedure.
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