Wiley Online Library : Advanced Healthcare Materials
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TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer

Intraperitoneal administration of immunogenic Toll-like receptor agonist-modified mesoporous silica nanoparticles leads to rapid internalization by ascites myeloid cells with trafficking to fat-associated lymphoid clusters. Activation of myeloid cells counters suppressive immune mechanisms associated with peritoneal metastasis, leading to regional...

Fri Nov 1, 2024 10:36
Biofilm Microenvironment‐Sensitive Anti‐Virulent and Immunomodulatory Nano‐on‐Nanodroplets to Combat Refractory Biofilm Infection Through Toxin Neutralization and Phagocytosis

A novel target-specific anti-virulent and immunomodulatory nano-on-nanodroplets of cationic nanoparticles shelled nanodroplets (C-AgND) is engineered for the effective treatment of biofilm-associated chronic wound infection. C-AgND exhibits an intrinsic biofilm EPS charge neutralization-based antibiofilm efficacy together with anti-virulence and an...

Fri Nov 1, 2024 10:36
Multi‐Target Peptide Nanofiber Immunotherapy Diminishes Complement Anaphylatoxin Activity in Acute Inflammation

This study investigates an active immunotherapy platform based on supramolecular peptides that can target two complement anaphylatoxins, C3a and C5a, to diminish acute inflammation. The materials’ modular construction allows for an investigation into the interaction between C3a and C5a, which shows that whereas anti-C5a antibody titers are protective,...

Thu Oct 31, 2024 11:36
A Closed‐Loop Cascade Strategy for On‐Demand Regulation of Uric Acid

A biocompatible network composite network (NW)-FPNP/uricase (UOX) is constructed with encapsulation of UOX and H2O2-activable xanthine oxidase (XOD) inhibitor febuxostat derivative. Uric acid (UA) level-dependent auto-adjustment of XOD and UOX activity is achieved through a closed-loop cascade reactions involving UOX-catalyzed UA metabolization, H2O2...

Wed Oct 30, 2024 11:05
Exos‐Loaded Gox‐Modified Smart‐Response Self‐Healing Hydrogel Improves the Microenvironment and Promotes Wound Healing in Diabetic Wounds

GOx-modified self-healing hydrogel directs the responsive degradation of the hydrogel by regulating the high glucose microenvironment and pH of diabetic wounds, which in turn releases active ingredients such as Exosomes. These active ingredients further ameliorate the problems of inflammation, infection, and insufficient blood supply that exist in...

Wed Oct 30, 2024 11:05
Molecular Engineering of Xanthene Dyes with 3D Multimodal‐Imaging Ability to Guide Photothermal Therapy

Four novel xanthene-derived PTAs are developed by fine-tuning the donor-π-acceptor system to strike a balance between radiative and nonradiative decay. In which, DMBA are effectively employed in fluorescence, 3D photoacoustic, and photothermal imaging-guiding tumor photothermal therapy. This work paves the way for leveraging xanthene fluorophores...

Wed Oct 30, 2024 11:05

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