BEIJING — The death toll from a collapsed highway in southeastern China climbed to 48 on Thursday as searchers dug for a second day through a treacherous and mountainous area. One side of the four-lane highway in the city of Meizhou gave way about 2 a.m. on Wednesday after a month of heavy rains in Guangdong province. Twenty-three...

President Ronald Reagan warned in 1986 that if Nicaragua’s “Sandinistas” remained in power, “terrorists and subversives” would have sanctuary “just 2 days’ driving time from Harlingen, Texas.” During the 1980s, Reagan gave more speeches on the Central American country than about almost any other foreign policy issue. Congress voted countless...

LOS ANGELES — Police removed barricades and began dismantling a pro-Palestinian demonstrators’ fortified encampment early Thursday at the University of California, Los Angeles, after hundreds of protesters defied orders to leave. Some people were detained, their hands bound with zip ties. The action came after officers spent hours...

In 2018, we worked with Bill Gates on a special issue of TIME dedicated to the power of optimism. Gates’ view, shared by many of the issue’s contributors, was that people are wired to focus on when things go wrong and when they don’t work. Sometimes this attention distracts us from the moments when progress is being made. Journalists fall...

Sometimes all it takes is a cold email to start a revolution. Dr. Alex Oshmyansky, a radiologist who had become incensed by the runaway prices of prescription drugs, decided to email billionaire and Dallas Mavericks owner Mark Cuban, who famously makes his contact info public. He included a business plan for a small company he had created...

Newly powerful weight-loss drugs became the biggest story in health in the past year—and Dr. Jens Juul Holst, Dr. Joel Habener, Svetlana Mojsov, and Dr. Daniel Drucker played pivotal roles in making those medications possible. The scientists conducted the early work, beginning in the 1970s, on glucagon-like peptides, or GLPs, that first...