The integration of phosphate-based glass into methylmethacrylate-based cement (PIMC) presents promising characteristics for vital pulp treatment. PIMC demonstrates persistent strength and stability in wet conditions, effectively controls initial inflammation, and stimulates human dental pulp stem cells. Overall, PIMC supports mineralized tissue repair...

Pseudo-3D topological patterns are created to study how topological cues affect smooth muscle cell (SMC) mechanotransduction and maturation, finding YAP involvement in phenotypic shifts. Comparative analysis with skeletal muscle cells reveals muscle type-dependent mechanosensing differences, providing insights into SMC regulation by topological cues...

An articular-cavity enriched lipid nanoparticle (LNP) formulation is optimized, and a rhFGF18 mRNA sequence for osteoarthritis (OA) therapy is designed. Utilizing the LNP-rhFGF18 mRNA complex via intra-articular injection, the disease progress is significantly ameliorated in the mouse OA model characterized by improved pain response and remodeling...

A “smarter” azobenzene-containing alginate material with multiple stimuli-responsiveness is designed. Such a biomaterial can perform isothermal phase transition between liquid crystal and isotropic liquid by responding to light, humidity and force at room temperature, which would be suitable for working as a new smart dressing material in biological...

Here, an effective mRNA nanovaccine platform using linker oligonucleotides (L-oligo) that can interact with mRNA and carrier lipids is presented. The oligonucleotide-linked lipid nanoparticles (lnLNP) can delivery vaccine mRNA and induce virus-specific immune responses in vivo. The current study provides a versatile strategy in the development of...

A biomimetic single-atom nanozyme (SAEs) nanodrug (named PFB) is developed. Upon entering cancer cells, the dual starvation effect induced by cold exposure therapy (CE) and BPTES can diminish intracellular glutathione (GSH), which can enhance the cytotoxic of SAEs. This strategy not only boosts reactive oxygen species in tumors, but also strengthens...