PLOS Biology
by Jingjing Wei, Jingtong Liu, Ziwen Wang, Yuan Yang, Yuwen Tian, Shengzhou Wang, Bao-Qing Gao, Song Gao, Li Yang, Junnan Tang, Yongming Wang CRISPR-Cas12a, often regarded as a precise genome editor, still requires improvements in specificity. In this study, we used a GFP-activation assay to screen 14 new Cas12a nucleases for mammalian genome editing,...
by Yassine Cherrak, Miguel Angel Salazar, Koray Yilmaz, Markus Kreuzer, Wolf-Dietrich Hardt The gastrointestinal tract is densely colonized by a polymicrobial community known as the microbiota which serves as primary line of defence against pathogen invasion. The microbiota can limit gut-luminal pathogen growth at different stages of infection....
by Leah R. Gerber, Gwenllian D. Iacona The planetary outlook for biodiversity is dire. A new collection of articles discusses the disconnect between the data we have and the data we need for more effective action on conservation, as well as how social justice and end-user viewpoints must be centered to ensure a more sustainable future for our planet....
by Mollie Virgo, Brian Thomas Ho, Serge Mostowy Zebrafish are often used to model host-pathogen interactions, but few models of natural virus infection have been established. A new study in PLOS Biology shows that metatranscriptomics and cohousing experiments can uncover a natural pathogenic virus of zebrafish for laboratory study. Zebrafish...
by Kayla J. Ripple, Charlotte Hudson, Emily Knight, Jason P. Landrum, Victoria Bell, Sarah L. Close Calls to support co-designed and usable science to inform management of natural resources are growing. Making the shift will require diverse collaborations between those who hold, share, and use knowledge. Calls to support co-designed and usable...
by Vanessa M. Adams There has been an increasingly prevalent message that data regarding costs must be included in conservation planning activities to make cost-efficient decisions. Despite the growing acceptance that socioeconomic context is critical to conservation success, the approaches to embedded economic and financial considerations into...