Chemotherapy exhibits unsatisfied efficacy because of the inefficient delivery of drugs, and mono-strategy based on active targeting or TME-responsive drug delivery can only improve a little. A library of stimuli-responsive aptamer-drug conjugates (srApDCs) is constructed as “dual-targeted” strategy for cancer treatment that enables targeted drug...

Abstract Platinum is the most widespread electrode material used for implantable biomedical and neuroelectronic devices, motivating exploring ways to improve its performance and understand its fundamental properties. Using reactive magnetron sputtering, we prepare PtOx, which upon partial reduction yields a porous thin-film form of Platinum with favorable...

Abstract Acoustic biofabrication has become an emerging strategy in tissue engineering due to its mild and fast manufacturing process. Herein, tissue-engineered cartilage constructs with high cell viability are fabricated from cell-laden gelatin microcarriers (GMs) through Faraday wave bioassembly, a typical acoustic “bottom-up” manufacturing process....

Abstract Photoacoustic imaging (PAI) can sensitively detect regions and substances with strong optical absorption, which means that diseased tissue can be imaged with high contrast in the presence of surrounding healthy tissue through the photoacoustic effect. However, its signal intensity and resolution may be limited by background signals generated...

Abstract Osteosarcoma (OS) is a “cold” tumour enriched in noninflammatory M2 phenotype tumour-associated macrophages (TAMs), which limits the efficacy of immunotherapy. The acidic tumour microenvironment (TME), generated by factors such as excess hydrogen (H+) ions and high lactate levels, activates immunosuppressive cells (e.g., M2 phenotype TAMs),...

Abstract Rapid propagation of tumor cells requires plenty of energy, which is adenosine triphosphate (ATP) dependent. ATP inhibition in tumors not only results in the starvation of tumor cells but also down-regulation of the level of heat shock proteins (HSPs), which usually increase during traditional photothermal therapy (PTT), especially when the...