Mazzaglia et al. describe an in vitro lymph node model (eLN), which replicates cellular and organizational features of the murine lymph node, incorporating primary lymphocytes, fibroblastic reticular cells, and lymphatic endothelium. T and B cells are compartmentalized and conduit-like structures are laser carved. When challenged with perfused stimuli,...

Abstract Glucocorticoids are widely used for treating allergic rhinitis, but conventional intranasal administration encounters unfavorable nasal cilia clearance and nasal mucosal barrier. Herein, a bilateral microneedle patch is fabricated for delivering cyclodextrin-based metal-organic frameworks (CD-MOF) encapsulating dexamethasone (DXMS) and paeonol...

Abstract Granular hydrogels composed of hydrogel microparticles are promising candidates for 3D bioprinting due to their ability to protect encapsulated cells. However, to achieve high print fidelity, hydrogel microparticles need to jam to exhibit shear-thinning characteristics, which is crucial for 3D printing. Unfortunately, this overpacking can...

Abstract Many cardiac diseases, such as arrhythmia or cardiogenic shock, cause irregular beating patterns that must be regulated to prevent disease progression towards heart failure. Treatments can include invasive surgery or high systemic drug dosages, which lack precision, localization, and control. Drug delivery systems (DDSs) that can deliver cargo...

The designed Rhe@Ag hydrogel dressing, combining silver ion and Rhein, synergistically promotes wound healing by antimicrobial and anti-inflammatory action. Rhein's self-assembly into hydrogel and coordination with Ag+ enhance mechanical stability and facilitate sustained drug release. Rhe@Ag fosters M1 to M2 macrophage transition, aiding tissue regeneration...

In this study, an injectable thermosensitive gel (CH-BPNs-NBP) is prepared for treating periodontitis. The designed thermosensitive gel serves as a controlled release system, delivering BPNs and NBP to the site of inflammation. CH-BPNs-NBP not only protects macrophages and human lymphatic endothelial cells from ROS attack but also promotes M2 polarization...